HRID2412845

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24247

Perchloric acid

HClO4

反应SMILES：COC(=O)CCCCCCCCCCCCCCCCCCCCC(=O)c1c(C)cc(OC)c(OC)c1O

HCID12824097

未命名化合物

PRODUCTS

产物

反应SMILES：COC(=O)CCCCCCCCCCCCCCCCCCCCCc1c(C)cc(OC)c(OC)c1O

HCID12824096

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

To a solution of methyl 21-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)heneicosanoate in acetic acid is added perchloric acid and catalytic reduction is carried out with 5% palladium-on-carbon. The reaction mixture is worked up as in the corresponding step of Reference Example 2 and the resultant product is recrystallized from ethanol. The above procedure yields methyl 22-(2-hydroxy-3,4-dimethoxy-6-methylphenyl)docosanoate as colorless needles, m.p. 71° C.-72.5° C.

WORKUP

后处理

customthe resultant product is recrystallized from ethanol

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-cbcfcb06645f4bf4a81500cf0953dc3c
来源数据集: uspto-grants-1985_01
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US04495104
来源说明: uspto-grants-1985_01

反应SMILES

[OH:1][C:2]1[C:33]([O:34][CH3:35])=[C:32]([O:36][CH3:37])[CH:31]=[C:30]([CH3:38])[C:3]=1[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])=O.Cl(O)(=O)(=O)=O>C(O)(=O)C.[Pd]>[OH:1][C:2]1[C:33]([O:34][CH3:35])=[C:32]([O:36][CH3:37])[CH:31]=[C:30]([CH3:38])[C:3]=1[CH2:4][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27]