Chlorotrimethylsilane → HCID 20431218, compound

Participants

Reaction Steps

10 g (0.03 mole) of 1-(p-tert.-butyl-phenyl)-2-methyl-3-(2,6-dimethylmorpholin-4-yl)-1-propanol (obtanied according to Example 2) were dissolved in 160 ml of petroleum ether with 4.4 ml of triethylamine at room temperature and 3.4 g of trimethylchlorosilane in 40 ml of petroleum ether were added dropwise. The precipitate was filtered off and the filtrate was concentrated. 12 g (98% of theory) of 1-(p-tert.-butyl-phenyl)-1-trimethylsilyloxy-2-methyl-3-(2,6-dimethylmorpholin-4-yl)-propane were obtained as a viscous oil.

Provenance & Evidence