Chlorotrimethylsilane → HCID 20431218, compound

HRID 2412853Notes

Reaction equation

HRID 2412853 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([OH:23])[CH:12]([CH3:22])[CH2:13][N:14]2[CH2:19][CH:18]([CH3:20])[O:17][CH:16]([CH3:21])[CH2:15]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:24][Si:25]([CH3:28])([CH3:27])Cl>C(N(CC)CC)C>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH:11]([O:23][Si:25]([CH3:28])([CH3:27])[CH3:24])[CH:12]([CH3:22])[CH2:13][N:14]2[CH2:15][CH:16]([CH3:21])[O:17][CH:18]([CH3:20])[CH2:19]2)=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 12768118HCID 12768118, compound

Product 1

HCID 20431218HCID 20431218, compoundYield 102.1%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

10 g (0.03 mole) of 1-(p-tert.-butyl-phenyl)-2-methyl-3-(2,6-dimethylmorpholin-4-yl)-1-propanol (obtanied according to Example 2) were dissolved in 160 ml of petroleum ether with 4.4 ml of triethylamine at room temperature and 3.4 g of trimethylchlorosilane in 40 ml of petroleum ether were added dropwise. The precipitate was filtered off and the filtrate was concentrated. 12 g (98% of theory) of 1-(p-tert.-butyl-phenyl)-1-trimethylsilyloxy-2-methyl-3-(2,6-dimethylmorpholin-4-yl)-propane were obtained as a viscous oil.

Workup

  1. filtrationThe precipitate was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-1703ea437e03455aaefc3111a5d08eac
Source dataset
uspto-grants-1985_01
Patent number
US04495184

Reaction notes

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