反应详情

A mixture consisting of 11.3 g. (0.52 mole) of 7-fluoro-4-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline, 115 ml. of 1N hydrochloric acid and 345 ml. of glacial acetic acid was refluxed for a period of three hours. Upon completion of this step, the reaction mixture was cooled to room temperature and poured over ice/water. The resulting mixture was then stirred for a period of 30 minutes and thereafter filtered to remove the precipitate, which was subsequently washed with water and air-dried to ultimately afford 8.9 g. (84%) of pure 7-fluoro-4-hydroxy-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. >300° C. Mass Spectrum: m/e, 204 (P).

1. filtrationfiltered
2. customto remove the precipitate, which
3. washwas subsequently washed with water
4. customair-dried to ultimately afford 8.9 g