Hydrochloric Acid → HCID 178437925, compound

HRID 2412875Notes

Reaction equation

HRID 2412875 reaction equation
[CH2:1]([C:3]1[N:7]2[C:8]3[C:13]([N:14]=[C:15]([O:16]C)[C:6]2=[N:5][N:4]=1)=[CH:12][C:11]([F:18])=[CH:10][CH:9]=3)[CH3:2].Cl>C(O)(=O)C>[CH2:1]([C:3]1[N:7]2[C:8]3[C:13]([N:14]=[C:15]([OH:16])[C:6]2=[N:5][N:4]=1)=[CH:12][C:11]([F:18])=[CH:10][CH:9]=3)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13385684HCID 13385684, compound

Product 1

HCID 178437925HCID 178437925, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture consisting of 11.3 g (0.046 mole) of 1-ethyl-7-fluoro-4-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline, 115 ml. of 1N hydrochloric acid and 345 ml. of glacial acetic acid was refluxed for a period of three hours. Upon completion of this step, the reaction mixture was cooled to room temperature and poured over ice/water. The resulting mixture was then stirred for a period of 30 minutes, filtered and the recovered solid product subsequently washed with water and air-dried to ultimately afford 6.6 g. (62%) of pure 1-ethyl-7-fluoro-4-hydroxy[1,2,4]triazolo[4,3-a]quinoxaline, m.p. >300° C. Mass Spectrum: m/e, 232 (P); m/e, 231 (P-1).

Workup

  1. filtrationfiltered
  2. washthe recovered solid product subsequently washed with water
  3. customair-dried to ultimately afford 6.6 g

Sources & evidence

ORD record
ord-01f9a95ee6204912aab5ef47b9378dfc
Source dataset
uspto-grants-1985_01
Patent number
US04495187

Reaction notes

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