Hydrochloric Acid → HCID 178517234, compound

HRID 2412878Notes

Reaction equation

HRID 2412878 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:12]=[N:13][N:14]=[C:7]1[C:6]([O:15]C)=[N:5]2.Cl>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:12]=[N:13][N:14]=[C:7]1[C:6]([OH:15])=[N:5]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13385687HCID 13385687, compound

Product 1

HCID 178517234HCID 178517234, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture consisting of 3.4 g. (0.014 mole) of 7-chloro-4-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline, 35 ml. of 1N hydrochloric acid and 105 ml. of glacial acetic acid was refluxed for a period of 2.5 hours. Upon completion of this step, the reaction mixture was cooled to room temperature and poured over ice/water. The resulting mixture was then stirred for a period of 20 minutes, filtered and the recovered solid product washed with water and air-dried to constant weight to ultimately afford 2.6 g. (87%) of pure 7-chloro-4-hydroxy-[1,2,4]triazolo[4,3-a]qunioxaline, m.p. >300° C.

Workup

  1. filtrationfiltered
  2. washthe recovered solid product washed with water
  3. customair-dried to constant weight to ultimately afford 2.6 g

Sources & evidence

ORD record
ord-14d1d6bf92ee4328b58d1851eea63c55
Source dataset
uspto-grants-1985_01
Patent number
US04495187

Reaction notes

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