4-Bromobenzylamine hydrochloride → HCID 61401012, compound

HRID 241290Notes

Reaction equation

HRID 241290 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7](Cl)(=[O:9])=[O:8])[CH:2]=1.Cl.[Br:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][NH2:18])=[CH:15][CH:14]=1>>[Br:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][NH:18][S:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)(=[O:9])=[O:8])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 27240964-Bromobenzylamine hydrochlorideHCID 3164136Pyridine-3-sulfonyl chloride

Product 1

HCID 61401012HCID 61401012, compoundYield 84%

Procedure

Reaction and post-treatment were carried out in the same manner as in Reference Example 2-(d) except for using 3-pyridylsulfonyl chloride (300 mg, 1.69 mmol), and using 4-bromobenzylamine hydrochloride (342 mg, 1.54 mmol) in place of (6-phenylpyridazin-3-ylmethyl)amine hydrochloride to afford the title compound (422 mg) as a white solid. (Yield: 84%)

Workup

  1. customReaction

Sources & evidence

ORD record
ord-24adc40dfafd44d699a5d2f1c4ab01b7
Source dataset
uspto-grants-2014_02
Patent number
US08648097B2

Reaction notes

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