反应详情

A slurry of 2.0 g. (0.01 mole) of 4-chloro-[1,2,4]triazolo[4,3-a]quinoxaline (the product of Example 2) in N,N-dimethylformamide (30 ml.) was saturated with monoethylamine gas and stirred at room temperature for 2 hours. Monoethylamine gas was again bubbled through the mixture and stirring was continued for 2 hours. The precipitate was removed by filtration and washed with N,N-dimethylformamide. Recrystallization from methanol afforded 680 mg. (32% yield) 4-ethylamino-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 254°-6° C. Mass spectrum: m/e, 213 (P).

1. customMonoethylamine gas was again bubbled through the mixture
2. stirringstirring
3. waitwas continued for 2 hours
4. customThe precipitate was removed by filtration
5. washwashed with N,N-dimethylformamide
6. customRecrystallization from methanol
7. customafforded 680 mg