Isopropylamine → HCID 13385716, compound

HRID 2412910Notes

Reaction equation

HRID 2412910 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].Cl[C:6]1[C:7]2[N:8]([C:16]([CH2:19][CH3:20])=[N:17][N:18]=2)[C:9]2[C:14]([N:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2>CN(C)C=O>[CH:1]([NH:4][C:6]1[C:7]2[N:8]([C:16]([CH2:19][CH3:20])=[N:17][N:18]=2)[C:9]2[C:14]([N:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 133857064-Chloro-1-ethyl[1,2,4]triazolo[4,3-a]quinoxaline

Product 1

HCID 13385716HCID 13385716, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Isopropylamine (1.77 g., 0.03 mole) was added to a solution of 4-chloro-1-ethyl-[1,2,4]triazolo-[4,3-a]quinoxaline (2.3 g., 0.01 mole), the product of Example 4, in N,N-dimethylformamide (30 ml.). Within 30 minutes, a precipitate formed. The reaction mixture was then stirred overnight at room temperature. The precipitate was separated by filtration and washed with N,N-dimethylformamide. Recrystallization from ethanol then gave 1.6 g. (63% yield) of 4-isopropylamino-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 222°-4° C. Mass spectrum: m/e, 255 (P).

Workup

  1. customa precipitate formed
  2. customThe precipitate was separated by filtration
  3. washwashed with N,N-dimethylformamide
  4. customRecrystallization from ethanol
  5. customthen gave 1.6 g

Sources & evidence

ORD record
ord-f9f3aa32d5544b7884a6ac5b5567dab2
Source dataset
uspto-grants-1985_01
Patent number
US04495187

Reaction notes

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