Ethylamine → HCID 13385717, compound

HRID 2412911Notes

Reaction equation

HRID 2412911 reaction equation
Cl[C:2]1[C:3]2[N:4]([C:12]([CH:15]([CH3:17])[CH3:16])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH2:18]([NH2:20])[CH3:19]>CN(C)C=O>[CH2:18]([NH:20][C:2]1[C:3]2[N:4]([C:12]([CH:15]([CH3:17])[CH3:16])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:19]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 13385708HCID 13385708, compound

Product 1

HCID 13385717HCID 13385717, compoundYield 22%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A slurry of 1.0 g. (0.004 mole) of 4-chloro-1-isopropyl-[1,2,4]triazolo[4,3-a]quinoxaline (the product of Example 6) in N,N-dimethylformamide (15 ml.) was saturated with monoethylamine gas and stirred at room temperature for 4 hours. The precipitate was separated by filtration and washed with N,N-dimethylformamide to afford 220 mg. (22% yield) of 4-ethylamino-1-isopropyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 209°-211° C. Mass spectrum: m/e, 255 (P).

Workup

  1. customThe precipitate was separated by filtration
  2. washwashed with N,N-dimethylformamide
  3. customto afford 220 mg

Sources & evidence

ORD record
ord-50396dbfa05f4b02bc69aa25b760689e
Source dataset
uspto-grants-1985_01
Patent number
US04495187

Reaction notes

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