Hydrochloric Acid → HCID 13370512, compound

HRID 2412924Notes

Reaction equation

HRID 2412924 reaction equation
[CH3:1][N:2]1[C:6]([C:7]([O:9]C)=[O:8])=[CH:5][C:4]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[N:3]1.CO.[OH-].[Na+].Cl>O>[CH3:1][N:2]1[C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]([C:11]2[CH:12]=[CH:13][C:14]([C:17]([F:18])([F:19])[F:20])=[CH:15][CH:16]=2)=[N:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 13370527HCID 13370527, compound

Product 1

HCID 13370512HCID 13370512, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Still following the procedure of Example 1, 6.8 g. of methyl 1-methyl-3-(4-trifluoromethylphenyl)pyrazole-5-carboxylate dissolved in 100 ml. of methanol was heated for about one hour with a solution of 1 g. of sodium hydroxide in 75 ml. of water. The reaction mixture was cooled and then acidified with 1N aqueous hydrochloric acid. The free acid, being insoluble in the acidic solution, separated and was collected by filtration. Recrystallization from benzene yielded 1-methyl-3-(4-trifluoromethylphenyl)pyrazole-5-carboxylic acid melting at 230°-2° C.

Workup

  1. temperatureThe reaction mixture was cooled
  2. customseparated
  3. filtrationwas collected by filtration
  4. customRecrystallization from benzene

Sources & evidence

ORD record
ord-235943bc0f9647b5804de90adaaf05bf
Source dataset
uspto-grants-1985_01
Patent number
US04495195

Reaction notes

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