2,2,2-Trifluoroacetaldehyde hydrate → HCID 13371359, compound

HRID 2412951Notes

Reaction equation

HRID 2412951 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][CH:10]=[CH:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.O.[F:21][C:22]([F:26])([F:25])[CH:23]=[O:24]>C1(C)C=CC=CC=1>[F:19][C:16]1[CH:17]=[CH:18][C:13]([C:12]2[CH:11]=[C:10]([CH:23]([C:22]([F:26])([F:25])[F:21])[OH:24])[NH:9][C:8]=2[C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 27813662,2,2-Trifluoroacetaldehyde hydrateHCID 111079192,3-bis(4-fluorophenyl)-1H-pyrrole

Product 1

HCID 13371359HCID 13371359, compoundYield 53.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 2.55 g (0.01 mole) of 2,3-bis(4-fluorophenyl)-1H-pyrrole and 1.3 g (0.011 mole) of trifluoroacetaldehyde hydrate in 75 ml toluene was heated at reflux for 3.5 hours. The mixture was concentrated on a rotary evaporator. The residue was purified by chromatography on silica gel to give 1.9 g of product, m.p. 121°-122°.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 hours
  3. concentrationThe mixture was concentrated on a rotary evaporator
  4. customThe residue was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-e528328f50bc42528ba376efed36e29d
Source dataset
uspto-grants-1985_01
Patent number
US04495196

Reaction notes

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