HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine → 7-(3-Ethylamino-2-hydroxypropoxy) flavone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | 7-(2,3-Epoxypropoxy)flavone | HCID 9948081 | — |
| Reactant | Ethanol hydrochloride | HCID 21887872 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-(3-Ethylamino-2-hydroxypropoxy) flavone hydrochloride | HCID 70449785 | 36% |
Reaction Steps
According to Method B, the title compound was synthesized from the reaction of 7-(2,3-epoxypropoxy) flavone and 70% aqueous ethylamine followed by treatment with HCl/EtOH, as white prisms, m.p. 244°-46° (MeOH) in 36% yield. The free base was obtained after column purification as white crystals, m.p. 164°-65° (MeOH/ehter), yield 39%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04495198 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-11cd8dc126ad42eb8dcdf99cea5699ef |
| Source note | uspto-grants-1985_01 |