HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitropropane → 5-Bromo-3-(2-methyl-2-nitropropyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitropropane | HCID 398 | — |
| Reactant | Indole, 5-bromo-3-(dimethylamino)methyl- | HCID 13249 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Diisopropyl Ether | HCID 7914 | — |
| Product | 5-Bromo-3-(2-methyl-2-nitropropyl)indole | HCID 12619661 | — |
Reaction Steps
5-Bromogramine, 60.0 g., 165 g. of 2-nitropropane, and 10.5 g. of sodium hydroxide pellets were caused to react under the conditions of Procedure 10C. The product was recovered as a dark syrup-like liquid from which the crystalline product was obtained by dissolving in i-Pr2O. The crystalline material was recrystallized from i-Pr2O to yield 48.6 g. of tan crystalline product, m.p. 106°-109°. The structure was confirmed by examination of the NMR spectrum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04495352 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-cc9d840aa0164f5180edf71ebc0b6051 |
| Source note | uspto-grants-1985_01 |