Methylamine → HCID 60010764, compound

HRID 2413072Notes

Reaction equation

HRID 2413072 reaction equation
[CH3:1][NH2:2].[C:3]([O:9][CH3:10])(=[O:8])[CH2:4][C:5]([CH3:7])=O>O>[CH3:1][NH:2]/[C:4](=[CH:5]\[CH3:7])/[C:3]([O:9][CH3:10])=[O:8]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 7757Methyl acetoacetate

Product 1

HCID 60010764HCID 60010764, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
20 °C

Procedure

At 5° to 10° C., 186 g (2.4 moles) of a 40% strength aqueous methylamine solution is dripped into a solution of 232 g (2 moles) of methyl acetoacetate in 150 ml of water. The mixture is then stirred for 12 hours at room temperature (20° C.). The product is then separated from the solution by suction filtration. After washing with ice water and drying under reduced pressure, there is obtained 212 g (82%) of a white solid; m.p.: 62°-63° C.

Workup

  1. customAt 5° to 10° C.
  2. customThe product is then separated from the solution by suction filtration
  3. washAfter washing with ice water
  4. customdrying under reduced pressure

Sources & evidence

ORD record
ord-bb7764ada02f40edb9d5bb943ba1276e
Source dataset
uspto-grants-1985_01
Patent number
US04496391

Reaction notes

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