Hydrazine hydrate (1:1) → HCID 13127488, compound

HRID 2413093Notes

Reaction equation

HRID 2413093 reaction equation
[CH2:1]([C:5]1[C:10]([F:11])=[C:9]([F:12])[C:8](F)=[C:7]([F:14])[C:6]=1[F:15])[CH2:2][CH2:3][CH3:4].O.[NH2:17][NH2:18]>C(O)C>[CH2:1]([C:5]1[C:10]([F:11])=[C:9]([F:12])[C:8]([NH:17][NH2:18])=[C:7]([F:14])[C:6]=1[F:15])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 140927181-Butyl-2,3,4,5,6-pentafluorobenzene

Product 1

HCID 13127488HCID 13127488, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

n-Butylpentafluorobenzene [19.0 g; described by J. M. Birchall and R. N. Haszeldine J. Chem. Soc p 3719 (1961)] was added to a solution of hydrazine hydrate (50 ml; 99-100% w/w) in ethanol (100 ml) and the mixture heated at reflux for 72 hours. The reaction mixture was cooled, evaporated to dryness to give a solid which was filtered off and washed with ethanol and hexane to give 4-n-butyl-2,3,5,6-tetrafluorophenylhydrazine (20.5 g), m.p. 80°-81° C., in the form of colourless crystals.

Workup

  1. temperaturethe mixture heated
  2. temperatureat reflux for 72 hours
  3. temperatureThe reaction mixture was cooled
  4. customevaporated to dryness
  5. customto give a solid which
  6. filtrationwas filtered off
  7. washwashed with ethanol and hexane

Sources & evidence

ORD record
ord-1114b08208de44f3aaca1bee558454d6
Source dataset
uspto-grants-1985_01
Patent number
US04496390

Reaction notes

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