Sodium Methoxide → HCID 20430096, compound

HRID 2413096Notes

Reaction equation

HRID 2413096 reaction equation
Cl[C:2]([CH3:20])([CH3:19])[C:3]([C:5]1[CH:18]=[CH:17][C:8]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])=[CH:7][CH:6]=1)=[O:4].[CH3:21][O-:22].[Na+]>CO>[CH3:21][O:22][C:2]([CH3:20])([CH3:19])[C:3]([C:5]1[CH:18]=[CH:17][C:8]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])=[CH:7][CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 20430156HCID 20430156, compound

Product 1

HCID 20430096HCID 20430096, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

28.7 g of 4-(2-chloro-2-methyl-propanoyl)-benzophenone and 5.4 g of sodium methoxide are boiled in 120 ml of methanol for 4 hours. After cooling, the mixture is filtered, the filtrate is evaporated and water is added to the residue. The mixture is extracted with ether and, after drying and evaporating the combined extracts, 4-(2methoxy-2-methyl-propanoyl)-benzophenone is obtained as a viscous oil.

Workup

  1. temperatureAfter cooling
  2. filtrationthe mixture is filtered
  3. customthe filtrate is evaporated
  4. additionwater is added to the residue
  5. extractionThe mixture is extracted with ether
  6. customafter drying
  7. customevaporating the combined extracts

Sources & evidence

ORD record
ord-85fc8edf76c743e186fe2e7b065ea13a
Source dataset
uspto-grants-1985_01
Patent number
US04496447

Reaction notes

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