2-Oxo-4-phenylbutyric acid → HCID 53834346, compound

HRID 2413103Notes

Reaction equation

HRID 2413103 reaction equation
O=[C:2]([CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:3]([OH:5])=[O:4].[NH2:14][C@H:15]([C:17]([N:19]([C:24]1[CH:28]=[CH:27][S:26][CH:25]=1)[CH2:20][C:21]([OH:23])=[O:22])=[O:18])[CH3:16].C([BH3-])#N.[Na+]>>[C:3]([CH:2]([NH:14][C@H:15]([C:17]([N:19]([C:24]1[CH:28]=[CH:27][S:26][CH:25]=1)[CH2:20][C:21]([OH:23])=[O:22])=[O:18])[CH3:16])[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([OH:5])=[O:4]

Participants

4

Reactant 3

HCID 697322-Oxo-4-phenylbutyric acidHCID 5003444Sodium cyanoborohydrideHCID 53922314HCID 53922314, compound

Product 1

HCID 53834346HCID 53834346, compound

Procedure

2-Oxo-4-phenylbutyric acid and L-alanyl-N-(3-thienyl)glycine are condensed in the presence of sodium cyanoborohydride to yield N-(1-carboxy-3-phenylpropyl)-L-alanyl-N-(3-thienyl)glycine.

Sources & evidence

ORD record
ord-e6e2bb1ca70c4ba1b123da3d94b3c2b7
Source dataset
uspto-grants-1985_01
Patent number
US04496542

Reaction notes

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