Hydrochloric Acid → SK&F 101055

HRID 2413112Notes

Reaction equation

HRID 2413112 reaction equation
[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9](C#N)[CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.Cl>C(O)(=O)C>[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13392479HCID 13392479, compound

Product 1

HCID 117762SK&F 101055

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The 6-chloro-3-cyano-2,3,4,5-tetrahydro-1H-3-benzazepine was refluxed for 19 hours in a mixture of 30 ml. of glacial acetic acid and 30 ml. of 6N hydrochloric acid. The mixture was concentrated in vacuo to yield 6-chloro-2,3,4,5-tetrahydro-1H-3-benzazepine as the hydrochloride salt of m.p. 214°-215° from ethanol. This salt in turn gave the base 6-chloro-2,3,4,5-tetrahydro-1H-3-benzazepine on treatment with dilute sodium hydroxide solution.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-6d0a57a318b141eebba82c106f79068b
Source dataset
uspto-grants-1985_01
Patent number
US04496558

Reaction notes

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