Acetaldehyde → HCID 20430479, compound

HRID 2413124Notes

Reaction equation

HRID 2413124 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[N:10][C:11]=1[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[N:8]([CH2:18][CH2:19][F:20])[CH:7]=[C:6]([C:21]([OH:23])=[O:22])[C:5]2=[O:24].[CH:25](=O)[CH3:26]>C(O)=O>[CH2:25]([N:15]1[CH2:16][CH2:17][N:12]([C:11]2[N:10]=[C:9]3[C:4]([C:5](=[O:24])[C:6]([C:21]([OH:23])=[O:22])=[CH:7][N:8]3[CH2:18][CH2:19][F:20])=[CH:3][C:2]=2[F:1])[CH2:13][CH2:14]1)[CH3:26]

Participants

4

Reactant 2

HCID 177AcetaldehydeHCID 30690021,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-1-(2-fluoroethyl)-4-oxo-7-(1-piperazinyl)-

Product 1

HCID 20430479HCID 20430479, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Using 6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid as a starting material, by reaction with acetoaldehyde in the presence of formic acid in accordance with the method of Example 1 is obtained 7-(4-ethyl-1-piperazinyl)-6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (compound 2) m.p. 223°-224° C.

Sources & evidence

ORD record
ord-080bc9cb11f64bb4833f5a6086e08a8e
Source dataset
uspto-grants-1985_01
Patent number
US04496566

Reaction notes

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