Methylamine → HCID 178485300, compound

HRID 2413141Notes

Reaction equation

HRID 2413141 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH:10]2[CH2:14][CH2:13][CH:12]([C:15]([O:17]C)=O)[CH2:11]2)[N:9]=1)[C:2]([NH2:4])=[NH:3].[CH3:19][NH2:20]>CCO>[CH3:19][NH:20][C:15]([CH:12]1[CH2:13][CH2:14][CH:10]([C:8]2[N:9]=[C:5]([NH:1][C:2]([NH2:4])=[NH:3])[S:6][CH:7]=2)[CH2:11]1)=[O:17]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178497561HCID 178497561, compound

Product 1

HCID 178485300HCID 178485300, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 3-(2-guanidinothiazol-4-yl)cyclopentane carboxylate (0.40 g.) and a solution of methylamine in EtOH (33% w/v; 15 ml.) was allowed to stand at ambient temperature for 60 hours. The solvent was removed by evaporation in vacuo and the residue was purified by medium pressure chromatography on silica gel using CHCl3 /MeOH/aqueous ammonia (s.g. 0.88) 8:2:0.3 v/v/v as eluant to give N-methyl-3-(2-guanidinothiazol-4-yl)cyclopentane carboxamide (0.27 g.), m.p. 216°-218°.

Workup

  1. customThe solvent was removed by evaporation in vacuo
  2. customthe residue was purified by medium pressure chromatography on silica gel

Sources & evidence

ORD record
ord-7b9e2d4eaaac43c49dbdf590ba2d1ccb
Source dataset
uspto-grants-1985_01
Patent number
US04496564

Reaction notes

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