Benzenebutanamine → HCID 20430539, compound

HRID 2413157Notes

Reaction equation

HRID 2413157 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][NH2:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CS[C:14]1[NH:19][C:18](=[O:20])[C:17]([CH2:21][C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)=[CH:16][N:15]=1>N1C=CC=CC=1>[OH2:20].[OH2:20].[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:14]2[NH:19][C:18](=[O:20])[C:17]([CH2:21][C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)=[CH:16][N:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 83242BenzenebutanamineHCID 127838233-Pyridylmethyl-2-methylthio-4-pyrimidone

Product 1

HCID 20430539HCID 20430539, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 4-phenylbutylamine (4.0 g), 2-methylthio-5-(3-pyridylmethyl)-4-pyrimidone (5.8 g) and dry pyridine (40 ml) was heated under reflux for 60 hours and evaporated to dryness. Water was added to the residue and the pH was adjusted to 7 with hydrochloric acid. The solid which separated out was recrystallised from aqueous ethanol to give 2-(4-phenylbutylamino)-5-(3-pyridylmethyl)-4-pyrimidone dihydrate m.p. about 70°.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 60 hours
  3. customevaporated to dryness
  4. additionWater was added to the residue
  5. customThe solid which separated out
  6. customwas recrystallised from aqueous ethanol

Sources & evidence

ORD record
ord-2c5ee3db23df4fd9af3a2ed953ab5c8a
Source dataset
uspto-grants-1985_01
Patent number
US04496567

Reaction notes

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