N-{6-Oxo-5-[(pyridin-3-yl)methyl]-1,6-dihydropyrimidin-2-yl}nitramide → HCID 20430495, compound

HRID 2413169Notes

Reaction equation

HRID 2413169 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:15]=[CH:14][C:8]([CH2:9][S:10][CH2:11][CH2:12][NH2:13])=[CH:7][CH:6]=1)[CH3:3].[N+](N[C:20]1[NH:25][C:24](=[O:26])[C:23]([CH2:27][C:28]2[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=2)=[CH:22][N:21]=1)([O-])=O>>[CH3:3][N:2]([CH2:4][C:5]1[CH:15]=[CH:14][C:8]([CH2:9][S:10][CH2:11][CH2:12][NH:13][C:20]2[NH:25][C:24](=[O:26])[C:23]([CH2:27][C:28]3[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=3)=[CH:22][N:21]=2)=[CH:7][CH:6]=1)[CH3:1]

Participants

3

Reactant 2

HCID 12788688N-{6-Oxo-5-[(pyridin-3-yl)methyl]-1,6-dihydropyrimidin-2-yl}nitramideHCID 12810610HCID 12810610, compound

Product 1

HCID 20430495HCID 20430495, compound

Procedure

Reaction of 2-[4-(dimethylaminomethyl)benzylthio]-ethylamine (1.7 g) with 2-nitroamino-5-(3-pyridylmethyl)-4-pyrimidone (1.7 g) in a similar manner to Example 7(iv) gave 2-[2-(4-(dimethylaminomethyl)benzylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone m.p. 127°-130°. A sample recrystallised a further time from acetonitrile had m.p. 124°-126°.

Sources & evidence

ORD record
ord-0248233e54ee42969bca799258c75e47
Source dataset
uspto-grants-1985_01
Patent number
US04496567

Reaction notes

Loading…