5-(3-Methoxybenzyl)-2-methylthio-4-pyrimidone → 2-[2-(3-Dimethylaminomethylbenzylthio)ethylamino]-5-(3-methoxybenzyl)-4-pyrimidone

HRID 2413172Notes

Reaction equation

HRID 2413172 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([CH:13]=[CH:14][CH:15]=1)[CH2:8][S:9][CH2:10][CH2:11][NH2:12])[CH3:3].[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:31]=[CH:32][CH:33]=1)[CH2:21][C:22]1[C:23](=[O:30])[NH:24][C:25](SC)=[N:26][CH:27]=1>N1C=CC=CC=1>[CH3:3][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([CH:13]=[CH:14][CH:15]=1)[CH2:8][S:9][CH2:10][CH2:11][NH:12][C:25]1[NH:24][C:23](=[O:30])[C:22]([CH2:21][C:20]2[CH:31]=[CH:32][CH:33]=[C:18]([O:17][CH3:16])[CH:19]=2)=[CH:27][N:26]=1)[CH3:1]

Participants

4

Reactant 2

HCID 129515265-(3-Methoxybenzyl)-2-methylthio-4-pyrimidoneHCID 129520192-[[3-(N,N-Dimethylaminomethyl)phenyl]methylthio]ethanamine

Product 1

HCID 204305242-[2-(3-Dimethylaminomethylbenzylthio)ethylamino]-5-(3-methoxybenzyl)-4-pyrimidone

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Reaction of 2-(3-dimethylaminomethylbenzylthio)ethylamine by heating under reflux for 40 hours in dry pyridine with 5-(3-methoxybenzyl)-2-methylthio-4-pyrimidone gives 2-[2-(3-dimethylaminomethylbenzylthio)ethylamino]-5-(3-methoxybenzyl)-4-pyrimidone.

Workup

  1. temperatureby heating

Sources & evidence

ORD record
ord-771e1bd592f04b14b92bd31cf32954f8
Source dataset
uspto-grants-1985_01
Patent number
US04496567

Reaction notes

Loading…