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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2413174Generated: October 27, 2026

2-Nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone → 2-[2-(3-(Dimethylaminomethyl)benzylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone

https://huagongshe.com/reaction/2413174

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidoneHCID 12783834—
Reactant2-[[3-(N,N-Dimethylaminomethyl)phenyl]methylthio]ethanamineHCID 12952019—
SolventEthanolHCID 702—
Product2-[2-(3-(Dimethylaminomethyl)benzylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidoneHCID 20430542—

Reaction Steps

Reaction of 2-[3-(dimethylaminomethyl)benzylthio]ethylamine with 2-nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone in refluxing ethanol gives 2-[2-(3-(dimethylaminomethyl)benzylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone which when reacted with boron tribromide gives 2-[2-(3-(dimethylaminomethyl)benzylthio)ethylamino]-5(4-hydroxy-2-pyridylmethyl)-4-pyrimidone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04496567
Source datasetuspto-grants-1985_01
ORD IDord-1f1e3b0cfc714ef2a17ca0154ead03d7
Source noteuspto-grants-1985_01