5-(5,6-Dimethyl-3-pyridylmethyl)-2-nitroamino4-pyrimidone → 2-[2-(3-(Dimethylaminomethyl)benzylthio)ethylamino]-5-(5,6-dimethyl-3-pyridylmethyl)-4-pyrimidone

HRID 2413175Notes

Reaction equation

HRID 2413175 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([CH:13]=[CH:14][CH:15]=1)[CH2:8][S:9][CH2:10][CH2:11][NH2:12])[CH3:3].[N+](N[C:20]1[NH:25][C:24](=[O:26])[C:23]([CH2:27][C:28]2[CH:29]=[N:30][C:31]([CH3:35])=[C:32]([CH3:34])[CH:33]=2)=[CH:22][N:21]=1)([O-])=O>C(O)C>[CH3:3][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([CH:13]=[CH:14][CH:15]=1)[CH2:8][S:9][CH2:10][CH2:11][NH:12][C:20]1[NH:25][C:24](=[O:26])[C:23]([CH2:27][C:28]2[CH:29]=[N:30][C:31]([CH3:35])=[C:32]([CH3:34])[CH:33]=2)=[CH:22][N:21]=1)[CH3:1]

Participants

4

Reactant 2

HCID 127838315-(5,6-Dimethyl-3-pyridylmethyl)-2-nitroamino4-pyrimidoneHCID 129520192-[[3-(N,N-Dimethylaminomethyl)phenyl]methylthio]ethanamine

Product 1

HCID 204305032-[2-(3-(Dimethylaminomethyl)benzylthio)ethylamino]-5-(5,6-dimethyl-3-pyridylmethyl)-4-pyrimidone

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reaction of 2-[3-(dimethylaminomethyl)benzylthio]ethylamine with an equimolar amount of 2-nitroamino-5-(5,6-dimethyl-3-pyridylmethyl)-4-pyrimidone by heating under reflux in ethanol for 48 hours gives 2-[2-(3-(dimethylaminomethyl)benzylthio)ethylamino]-5-(5,6-dimethyl-3-pyridylmethyl)-4-pyrimidone.

Workup

  1. temperatureby heating

Sources & evidence

ORD record
ord-a1c6ec4f9f86414b9ab74e9804011d66
Source dataset
uspto-grants-1985_01
Patent number
US04496567

Reaction notes

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