Hydrochloric Acid → HCID 70456365, compound

HRID 2413224Notes

Reaction equation

HRID 2413224 reaction equation
C([O:3][C:4]([C:6]1[CH:21]=[CH:20][C:9]2[S:10][C:11]([CH2:14][C:15]3[NH:16][CH:17]=[CH:18][N:19]=3)=[C:12]([CH3:13])[C:8]=2[CH:7]=1)=[O:5])C.[ClH:22]>>[ClH:22].[NH:19]1[CH:18]=[CH:17][N:16]=[C:15]1[CH2:14][C:11]1[S:10][C:9]2[CH:20]=[CH:21][C:6]([C:4]([OH:5])=[O:3])=[CH:7][C:8]=2[C:12]=1[CH3:13]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 70457205HCID 70457205, compound

Product 1

HCID 70456365HCID 70456365, compound

Procedure

A mixture of 2-(1-imidazolylmethyl)-3-methylbenzo[b]thiophene-5-carboxylic acid ethyl ester (1.0 g) and 6N hydrochloric acid (80 ml) was heated on a steam bath for 5 hours and then cooled. The solid was filtered off, dried and crystallized from ethano/ether to give 2-(1-imidazolylmethyl)-3-methylbenzo[b]thiophene-5-carboxylic acid hydrochloride (0.72 g), m.p. 298°-299° C.

Workup

  1. temperaturewas heated on a steam bath for 5 hours
  2. temperaturecooled
  3. filtrationThe solid was filtered off
  4. customdried
  5. customcrystallized from ethano/ether

Sources & evidence

ORD record
ord-eee2e66130a244ac8d9f4c4b4efcb061
Source dataset
uspto-grants-1985_01
Patent number
US04496572

Reaction notes

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