Sodium Bicarbonate → 7-Bromo-2-dimethylaminomethyl-1-tetralone

HRID 2413265Notes

Reaction equation

HRID 2413265 reaction equation
Cl.[Br:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH:9]([CH2:14][N:15]([CH3:17])[CH3:16])[C:10]2=[O:13])=[CH:5][CH:4]=1.C(=O)(O)[O-].[Na+]>O>[Br:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH:9]([CH2:14][N:15]([CH3:17])[CH3:16])[C:10]2=[O:13])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 233209337-Bromo-2-dimethylaminomethyl-1-tetralone hydrochloride

Product 1

HCID 136630577-Bromo-2-dimethylaminomethyl-1-tetralone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The hydrochloride was converted to the free base by dissolving in a small volume of water and adding a slight excess of a saturated aqueous solution of sodium bicarbonate. Ether extraction gave the free base as an oil.

Workup

  1. extractionEther extraction

Sources & evidence

ORD record
ord-bee6607278a643528c10786613638970
Source dataset
uspto-grants-1985_01
Patent number
US04496572

Reaction notes

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