Methanol → HCID 131714091, compound

HRID 2413310Notes

Reaction equation

HRID 2413310 reaction equation
[C:1]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][C:4]([Si:7](Cl)([CH2:9]Cl)[CH3:8])=[CH:3][CH:2]=1.[Na].[NH:19]1[CH:23]=[CH:22][N:21]=[CH:20]1.[CH3:24][OH:25]>CN(C)C=O.O>[C:1]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][C:4]([SiH:7]([CH2:9][N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[CH2:8][O:25][CH3:24])=[CH:3][CH:2]=1

Participants

6

Reactant 3

HCID 887MethanolHCID 54452988HCID 54452988, compoundHCID 57373095Imidazole sodium

Product 1

HCID 131714091HCID 131714091, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of (1,1'-biphenyl-4-yl)chloro(chloromethyl)methylsilane and two equivalents of imidazole sodium salt in dimethylformamide is warmed to 80°-90° C. for 2 hours. Ten equivalents of methanol is then added, and the mixture is held at 70° for 1 hour, cooled, diluted with water, and quickly extracted with ether. Washing the ether solution with water and brine, drying over magnesium sulfate, and evaporation leaves the title compound.

Workup

  1. temperatureis warmed to 80°-90° C. for 2 hours
  2. temperaturecooled
  3. extractionquickly extracted with ether
  4. washWashing the ether solution with water and brine
  5. dry with materialdrying over magnesium sulfate, and evaporation

Sources & evidence

ORD record
ord-eb7b342633104608b09ea5224277d9ad
Source dataset
uspto-grants-1985_01
Patent number
US04496551

Reaction notes

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