反应详情

t-Butyl-5-(p-fluorobenzoyl)-7-t-butoxycarbonyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate (1 mmole) is dissolved in 5 ml of trifluoroacetic acid. The reaction mixture is heated at reflux for 5 hours before it is evaporated in vacuo to remove most of the solvent. The resulting oil is triturated with about 10 ml of water, filtered and dried in vacuo to afford 5-(p-fluorobenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 5 hours before it
3. customis evaporated in vacuo
4. customto remove most of the solvent
5. customThe resulting oil is triturated with about 10 ml of water
6. filtrationfiltered
7. customdried in vacuo