HCID 20430445, compound → HCID 20430412, compound

HRID 2413420Notes

Reaction equation

HRID 2413420 reaction equation
C([O:14][C:15]([C:17]1[N:18]2[CH:21]([S:22][CH2:23][C:24]=1[C:25]1[S:29][C:28]([N:30]([CH3:32])[CH3:31])=[N:27][CH:26]=1)[CH:20]([NH:33][C:34](=[O:41])[CH2:35][C:36]1[S:37][CH:38]=[CH:39][CH:40]=1)[C:19]2=[O:42])=[O:16])(C1C=CC=CC=1)C1C=CC=CC=1>C(O)=O>[C:15]([C:17]1[N:18]2[CH:21]([S:22][CH2:23][C:24]=1[C:25]1[S:29][C:28]([N:30]([CH3:31])[CH3:32])=[N:27][CH:26]=1)[CH:20]([NH:33][C:34](=[O:41])[CH2:35][C:36]1[S:37][CH:38]=[CH:39][CH:40]=1)[C:19]2=[O:42])([OH:16])=[O:14]

Participants

3

Reactant 1

HCID 20430445HCID 20430445, compound

Product 1

HCID 20430412HCID 20430412, compoundYield 59.9%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

2-Benzhydryloxycarbonyl-3-(2-dimethylamino-thiazol-5-yl)-8-oxo-7-(thien-2-yl-acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene (2.4 g) is treated with formic acid (25 cc) in accordance with the working method described in Example 17, and 2-carboxy-3-(2-dimethylamino-thiazol-5-yl)-8-oxo-7-(thien-2-yl-acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene (1.05 g) is obtained, as the inner salt, in the form of a yellow solid.

Sources & evidence

ORD record
ord-5a3c0f05a9994d3c9ba0fe342031cf04
Source dataset
uspto-grants-1985_01
Patent number
US04496560

Reaction notes

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