Methanesulfonic Acid → HCID 13175954, compound

HRID 2413434Notes

Reaction equation

HRID 2413434 reaction equation
[CH:1]([O:14][C:15]([C:17]1[N:18]2[CH:21]([S:22][CH2:23][C:24]=1[C:25]1[S:29][CH:28]=[N:27][CH:26]=1)[CH:20]([NH:30]C(OC(C)(C)C)=O)[C:19]2=[O:38])=[O:16])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CS(O)(=O)=O>C(#N)C>[NH2:30][CH:20]1[C:19](=[O:38])[N:18]2[CH:21]1[S:22][CH2:23][C:24]([C:25]1[S:29][CH:28]=[N:27][CH:26]=1)=[C:17]2[C:15]([O:14][CH:1]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:16]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 13175941HCID 13175941, compound

Product 1

HCID 13175954HCID 13175954, compoundYield 100.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the working method described in Example 15, 2-benzhydryloxycarbonyl-7-t-butoxycarbonylamino-8-oxo-3-(thiazol-5-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene (10 g) is treated with methanesulphonic acid (10 cc) in acetonitrile (100 cc). 7-Amino-2-benzhydryloxycarbonyl-8-oxo-3-(thiazol-5-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene (8.2 g) is obtained in the form of a yellow solid.

Sources & evidence

ORD record
ord-6c75cfe7723c4d318fcfbd20080261e7
Source dataset
uspto-grants-1985_01
Patent number
US04496560

Reaction notes

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