Trifluoroacetic acid → HCID 20276296, compound

HRID 2413435Notes

Reaction equation

C([O:14][C:15]([C:17]1[N:18]2[CH:21]([S:22][CH2:23][C:24]=1[C:25]1[S:29][CH:28]=[N:27][CH:26]=1)[CH:20]([NH:30]C(OC(C)(C)C)=O)[C:19]2=[O:38])=[O:16])(C1C=CC=CC=1)C1C=CC=CC=1.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>>[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42].[NH2:30][CH:20]1[C:19](=[O:38])[N:18]2[CH:21]1[S:22][CH2:23][C:24]([C:25]1[S:29][CH:28]=[N:27][CH:26]=1)=[C:17]2[C:15]([OH:16])=[O:14]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 13175941HCID 13175941, compound

Product 1

HCID 20276296HCID 20276296, compound

Procedure

Following the working method described in Example 6, 2-benzhydryloxycarbonyl-7-t-butoxycarbonylamino-8-oxo-3-(thiazol-5-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene (5.2 g) is treated with trifluoroacetic acid (80 cc). 7-Amino-2-carboxy-8-oxo-3-(thiazol-5-yl)-5-thia-1-azabicyclo[4.2.0]-oct-2-ene trifluoroacetate (4 g) is obtained in the form of a cream-coloured solid.

Sources & evidence

ORD record: ord-24908e6ab86d46fd957b6a3e9c34ab1b
Source dataset: uspto-grants-1985_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04496560

Reaction notes

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