HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 7-Amino-2-benzhydryloxycarbonyl-3-(2-nicotinoylamino-thiazol-5-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 2-Benzhydryloxycarbonyl-7-t-butoxycarbonylamino-3-(2-nicotinoylaminothiazol-5-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene | HCID 20402455 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 7-Amino-2-benzhydryloxycarbonyl-3-(2-nicotinoylamino-thiazol-5-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene | HCID 20430428 | 84% |
Reaction Steps
2-Benzhydryloxycarbonyl-7-t-butoxycarbonylamino-3-(2-nicotinoylamino-thiazol-5-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (9 g) in acetonitrile (134 cc) is treated with p-toluenesulphonic acid (7.6 g) according to the working method described in Example 24, to give 7-amino-2-benzhydryloxycarbonyl-3-(2-nicotinoylamino-thiazol-5-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (6.43 g) in the form of a cream powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04496560 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-75f8d224c6e8428588f421f5c0573bc5 |
| Source note | uspto-grants-1985_01 |