HRID2413448

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

反应SMILES：CC(C)(C)OC(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(c3cnc(NC(=O)c4cccnc4)s3)CSC12

HCID20402455

未命名化合物

PRODUCTS

产物

反应SMILES：NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(c3cnc(NC(=O)c4cccnc4)s3)CSC12

HCID20430428

未命名化合物

收率 84%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

2-Benzhydryloxycarbonyl-7-t-butoxycarbonylamino-3-(2-nicotinoylamino-thiazol-5-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (9 g) in acetonitrile (134 cc) is treated with p-toluenesulphonic acid (7.6 g) according to the working method described in Example 24, to give 7-amino-2-benzhydryloxycarbonyl-3-(2-nicotinoylamino-thiazol-5-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (6.43 g) in the form of a cream powder.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-75f8d224c6e8428588f421f5c0573bc5
来源数据集: uspto-grants-1985_01
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US04496560
来源说明: uspto-grants-1985_01

反应SMILES

[CH:1]([O:14][C:15]([C:17]1[N:18]2[CH:21]([S:22][CH2:23][C:24]=1[C:25]1[S:29][C:28]([NH:30][C:31](=[O:38])[C:32]3[CH:37]=[CH:36][CH:35]=[N:34][CH:33]=3)=[N:27][CH:26]=1)[CH:20]([NH:39]C(OC(C)(C)C)=O)[C:19]2=[O:47])=[O:16])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C(#N)C>[NH2:39][CH:20]1[C:19](=[O:47])[N:18]2[CH:21]1[S:22][CH2:23][C:24]([C:25]1[S:29][C:28]([NH:30][C:31](=[O:38])[C:32]3[CH:37]=[CH:36][CH:35]=[N:34][CH:33]=3)=[N:27][CH:26]=1)=[C:17]2[C:15]([O:14][CH:1]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:16]