(Ethoxycarbonylmethyl)triphenylphosphonium → HCID 53853771, compound

HRID 2413450Notes

Reaction equation

HRID 2413450 reaction equation
C[O-].[Na+].[Cl:4][C:5]1[CH:6]=[N:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[C:10]([Cl:15])[C:9]=2[CH:16]=[O:17].[CH2:18]([O:20][C:21]([CH2:23][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=O)[CH3:19]>CO.C(O)C>[Cl:4][C:5]1[CH:6]=[N:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[C:10]([Cl:15])[C:9]=2[C:16](=[O:17])[CH:19]=[CH:18][O:20][CH2:21][CH3:23]

Participants

6

Reactant 3

HCID 73732(Ethoxycarbonylmethyl)triphenylphosphoniumHCID 10942334Sodium MethoxideHCID 13090787HCID 13090787, compound

Product 1

HCID 53853771HCID 53853771, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

36 ml of a 15% strength solution of sodium methylate in methanol were added dropwise, at 20° C., to a suspension of 22.6 g of 3,7-dichloro-8-formylquinoline and 38.4 g of ethoxycarbonylmethyl-triphenyl-phosphonium chloide in 200 ml of ethanol. The mixture was stirred for 3 hours, after which the precipitate was filtered off under suction, washed with water and dried.

Workup

  1. filtrationafter which the precipitate was filtered off under suction
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-0601905ab212409aaa373c77feecf319
Source dataset
uspto-grants-1988_01
Patent number
US04717416

Reaction notes

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