Acetic Acid → HCID 54127815, compound

HRID 2413451Notes

Reaction equation

HRID 2413451 reaction equation
C[O-].[Na+].[Cl:4][C:5]1[CH:6]=[N:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[C:10]([Cl:15])[C:9]=2[CH:16]=O.[CH3:18][C:19]([C:21]1[CH:22]=[CH:23][C:24]([OH:27])=[CH:25][CH:26]=1)=O.[Cl-].C1([PH+](C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(O)(=O)C>CO.C(O)C>[Cl:4][C:5]1[CH:6]=[N:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[C:10]([Cl:15])[C:9]=2[CH:16]=[CH:18][CH2:19][C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=1

Participants

7

Reactant 4

HCID 176Acetic AcidHCID 10942334Sodium MethoxideHCID 13090787HCID 13090787, compoundHCID 86741956HCID 86741956, compound

Product 1

HCID 54127815HCID 54127815, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

36 ml of a 15% strength solution of sodium methylate in methanol were added to 11 g of 3,7-dichloro-8-formylquinoline and 21.6 g of 4-hydroxyacetophenone-triphenylphosphonium chloride in 150 ml of ethanol. The mixture was stirred for 21/2 hours at 20° C., after which 3 ml of glacial acetic acid were added and the precipitate was filtered off under suction, washed with water and dried.

Workup

  1. filtrationthe precipitate was filtered off under suction
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-e7e2b04f662f42a8a83157e311725dcc
Source dataset
uspto-grants-1988_01
Patent number
US04717416

Reaction notes

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