反应详情

4.3 g of 6-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide, 3.1 g of 3-methoxybenzyl chloride and 2.8 g of finely powdered potassium carbonate are first stirred at room temperature for 2 hours and then at 80° C. for 5 hours. After cooling, the solvent is removed in vacuo, the residue is taken up with water/methylene chloride, and the organic phase is again shaken with water and dried over magnesium sulfate. After evaporation in a rotary evaporator, a yellow oil remains, and this crystallizes after trituration with ethyl acetate.

1. temperatureAfter cooling
2. customthe solvent is removed in vacuo
3. dry with materialdried over magnesium sulfate
4. customAfter evaporation
5. customin a rotary evaporator
6. customthis crystallizes after trituration with ethyl acetate