Hydrogen Bromide → 6-Hydroxy-2-n-octyl-1,2,3,4-tetrahydroisoquinoline hydrobromide

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Reaction Steps

5.8 g of the compound prepared under (b) are heated under reflux for 16 hours with a mixture of 100 ml of glacial acetic acid and 48% strength aqueous hydrobromic acid in the volume ratio 1:1. After cooling, the acid mixture is distilled off under waterpump vacuum, and the residue is boiled with a little ethanol. On cooling and scratching, 4.0 g of colorless crystals crystallize out (47% of theory over all stages), melting point: 165-166°.

Provenance & Evidence