Hydrochloric Acid → HCID 20155817, compound

HRID 2413499Notes

Reaction equation

HRID 2413499 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)=[CH:4][CH:3]=1.[CH2:19]=O.Cl>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:9][CH2:10][C:11]3[C:16](=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=3)[CH2:19]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 133619124-Chloro-N-[2-(3-methoxyphenyl)ethyl]aniline

Product 1

HCID 20155817HCID 20155817, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

14.4 g of the product described under (a), 6 ml of 35% strength aqueous formaldehyde solution and 10 ml of concentrated hydrochloric acid in 20 ml of methanol are heated under reflux for 1 day. On distilling off the methanol, the product crystallizes out. After cooling, it is filtered off with suction and the resulting product (13.5 g, 91% of theory) is reacted further under (c) without further purification.

Workup

  1. temperatureare heated
  2. temperatureunder reflux for 1 day
  3. distillationOn distilling off the methanol
  4. customthe product crystallizes out
  5. temperatureAfter cooling
  6. filtrationit is filtered off with suction
  7. customthe resulting product (13.5 g, 91% of theory) is reacted further under (c) without further purification

Sources & evidence

ORD record
ord-a996f3aec72443e1ac124e3d641ce8ce
Source dataset
uspto-grants-1988_01
Patent number
US04717724

Reaction notes

Loading…