HCID 178447987, compound → HCID 178450574, compound

HRID 2413526Notes

Reaction equation

HRID 2413526 reaction equation
[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][CH2:11][C@H:12]2[CH2:17][CH2:16][C@H:15]([OH:18])[CH2:14][CH2:13]2)[CH2:6][CH2:5]1)[CH2:2][CH3:3]>C1COCC1>[CH2:4]([O:18][C@H:15]1[CH2:14][CH2:13][C@H:12]([CH2:11][CH2:10][C@H:7]2[CH2:8][CH2:9][C@H:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6]2)[CH2:17][CH2:16]1)[CH2:1][CH2:2][CH3:3]

Participants

3

Reactant 1

HCID 178447987HCID 178447987, compound

Product 1

HCID 178450574HCID 178450574, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.5 g of 35% KH dispersion is added to a solution of 0.9 g of trans-4-[2-(trans-4-n-propylcyclohexyl)ethyl]-cyclohexanol in 250 ml of THF and stirring is carried out for two hours under reflux. Then 0.6 g of n-iodobutane is added and stirring is carried out for two hours at room temperature. Excess potassium hydride is destroyed with water. Extraction is carried out with methylene chloride, drying is carried with Na2SO4 and the solvent evaporated off. The residue left behind is worked up chromatographically. 1-(trans-4-n-butoxycyclohexyl)-2-(trans-4-n-propylcyclohexyl)ethane is obtained.

Workup

  1. temperatureunder reflux
  2. stirringstirring
  3. waitis carried out for two hours at room temperature
  4. customExcess potassium hydride is destroyed with water
  5. extractionExtraction
  6. customdrying
  7. customthe solvent evaporated off
  8. waitThe residue left behind

Sources & evidence

ORD record
ord-dd5673788cb84945b6466ae1cbbeb1d4
Source dataset
uspto-grants-1988_01
Patent number
US04719032

Reaction notes

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