Acetic Anhydride → HCID 67361589, compound

HRID 2413538Notes

Reaction equation

HRID 2413538 reaction equation
[C:1]([O:4][C:5](=[O:7])[CH3:6])(=O)[CH3:2].O[C@@H]1[C@H:15]2[C@H:16]3[C@H:25]([CH2:26][CH2:27][C@:12]2([CH2:13][CH3:14])[C:11](=[O:29])C1)[C@@H:24]1[C:19](=[CH:20][C:21](=[O:28])[CH2:22][CH2:23]1)[CH2:18][CH2:17]3>N1C=CC=CC=1>[C:5]([O:4][C@@H:1]1[C@H:15]2[C@H:16]3[C@H:25]([CH2:26][CH2:27][C@:12]2([CH2:13][CH3:14])[C:11](=[O:29])[CH2:2]1)[C@@H:24]1[C:19](=[CH:20][C:21](=[O:28])[CH2:22][CH2:23]1)[CH2:18][CH2:17]3)(=[O:7])[CH3:6]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 15513180(15α)-13-Ethyl-15-hydroxygon-4-ene-3,17-dione

Product 1

HCID 67361589HCID 67361589, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

200 ml of acetic anhydride is added dropwise to 100 g of 15α-hydroxy-18-methyl-4-estrene-3,17-dione in 350 ml of pyridine. After one hour, the reaction mixture is stirred into ice water. The thus-precipitated product is suctioned off, washed neutral with water, and dried under vacuum at 50° C., thus obtaining 100 g of 15α-acetoxy-18-methyl-4-estrene-3,17-dione. A sample recrystallized from acetone/hexane melts at 165° C.

Workup

  1. washwashed neutral with water
  2. customdried under vacuum at 50° C.

Sources & evidence

ORD record
ord-65a6a9582bba4209aaeb9cc3c4acf79d
Source dataset
uspto-grants-1988_01
Patent number
US04719054

Reaction notes

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