2,2-Dimethoxypropane → HCID 70389428, compound

HRID 2413542Notes

Reaction equation

HRID 2413542 reaction equation
[C:1]([O:9][C@@H:10]1[C@H:16]2[C@H:17]3[C@H:26]([CH2:27][CH2:28][C@:13]2([CH2:14][CH3:15])[C:12](=[O:30])[CH2:11]1)[C@@H:25]1[C:20](=[CH:21][C:22](=[O:29])[CH2:23][CH2:24]1)[CH2:19][CH2:18]3)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:31]OC(OC)(C)C>>[C:1]([O:9][C@@H:10]1[C@H:16]2[C@H:17]3[C@H:26]([CH2:27][CH2:28][C@:13]2([CH2:14][CH3:15])[C:12](=[O:30])[CH2:11]1)[C@@H:25]1[C:20]([CH:21]=[C:22]([O:29][CH3:31])[CH2:23][CH2:24]1)=[CH:19][CH2:18]3)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 64952,2-DimethoxypropaneHCID 67361620HCID 67361620, compound

Product 1

HCID 70389428HCID 70389428, compound

Procedure

Analogously to Direction II(b), 7.8 g of 15α-benzoyloxy-18-methyl-4-estrene-3,17-dione is reacted with dimethoxypropane and worked up, thus obtaining 6.8 g of 15α-benzoyloxy-3-methoxy-18-methyl-3,5-estradien-17-one as a foam.

Sources & evidence

ORD record
ord-c6fb7bdf4ef24f078855315a78bc2554
Source dataset
uspto-grants-1988_01
Patent number
US04719054

Reaction notes

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