2,2-Dimethoxypropane → HCID 70388515, compound

HRID 2413543Notes

Reaction equation

HRID 2413543 reaction equation
[CH3:1][CH2:2][C@:3]12[CH2:19][CH2:18][C@H:17]3[C@@H:8]([CH2:9][CH2:10][C:11]4[C@@H:16]3[CH2:15][CH2:14][C:13](=[O:20])[CH:12]=4)[C@@H:7]1[C@@H:6]([O:21][C:22](=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24])[CH2:5][C:4]2=[O:28].[CH3:29]OC(OC)(C)C>>[CH3:29][O:20][C:13]1[CH2:14][CH2:15][C@H:16]2[C:11](=[CH:10][CH2:9][C@@H:8]3[C@@H:17]2[CH2:18][CH2:19][C@@:3]2([CH2:2][CH3:1])[C@H:7]3[C@@H:6]([O:21][C:22](=[O:27])[C:23]([CH3:24])([CH3:26])[CH3:25])[CH2:5][C:4]2=[O:28])[CH:12]=1

Participants

3

Reactant 2

HCID 64952,2-DimethoxypropaneHCID 70388709HCID 70388709, compound

Product 1

HCID 70388515HCID 70388515, compound

Procedure

In analogy to Direction II(b), 5.6 g of 18-methyl-15α-trimethylacetoxy-4-estrene-3,17-dione is reacted with dimethoxypropane and worked up, thus obtaining 4.9 g of 3-methoxy-18-methyl-15α-trimethylacetoxy-3,5-estradien-17-one.

Sources & evidence

ORD record
ord-661037206e4948a690dcb6cd38b67ebe
Source dataset
uspto-grants-1988_01
Patent number
US04719054

Reaction notes

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