Tris(hydroxymethyl)aminomethane → HCID 14391238, compound

HRID 2413621Notes

Reaction equation

HRID 2413621 reaction equation
[Cl:1][C:2]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([CH:16]=O)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[CH:7]2.[CH2:18]([OH:25])[C:19]([NH2:24])([CH2:22][OH:23])[CH2:20][OH:21]>CCO.CCOCC>[ClH:1].[Cl:1][C:2]1[C:3]2[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=2)[C:9]([CH2:16][NH:24][C:19]([CH2:22][OH:23])([CH2:20][OH:21])[CH2:18][OH:25])=[C:10]2[C:15]=1[CH:14]=[CH:13][CH:12]=[CH:11]2

Participants

4

Reactant 2

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 8270310-Chloro-9-anthraldehyde

Product 1

HCID 14391238HCID 14391238, compound

Reagents, catalysts & solvents 1

HCID 21585056Diethyl ether ethanolSolvent

Procedure

Using the reductive amination procedure described in 1, 10 -chloroanthracene-9-carbaldehyde (Aldrich) and tris(hydroxymethyl)aminomethane (Aldrich) gave 2-((10-chloro-9-anthracenylmethyl)amino)-2-hydroxymethyl-1,3-propanediol hydrochloride, mp 251°-254° (dec), (EtOH/Et2O), (C,H,Cl,N).

Sources & evidence

ORD record
ord-93d51bb8805e4114a6533e7e21a92e17
Source dataset
uspto-grants-1988_01
Patent number
US04719047

Reaction notes

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