2-Amino-2-methyl-1,3-propanediol → HCID 13375288, compound

HRID 2413629Notes

Reaction equation

HRID 2413629 reaction equation
[Cl:1][CH2:2][CH2:3][C:4]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([CH:18]=O)=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[CH:9]2.[NH2:20][C:21]([CH3:26])([CH2:24][OH:25])[CH2:22][OH:23]>>[ClH:1].[Cl:1][CH2:2][CH2:3][C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:11]([CH2:18][NH:20][C:21]([CH3:26])([CH2:24][OH:25])[CH2:22][OH:23])=[C:12]2[C:17]=1[CH:16]=[CH:15][CH:14]=[CH:13]2

Participants

3

Reactant 2

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 13375393HCID 13375393, compound

Product 1

HCID 13375288HCID 13375288, compound

Procedure

Using the reductive amination procedure outlined in 1, 10-(2-chloroethyl)-9-anthracenecarbaldehyde (4A) and 2-amino-2-methyl-1,3-propanediol (Aldrich) gave 2-(((10-(2-chloroethyl)-9-anthracenyl)methyl)amino)-2-methyl-1,3-propanediol hydrochloride mp 229°-231° (dec), (EtOH/Et2O), (C, H, Cl, N).

Sources & evidence

ORD record
ord-9f9d45d619c14897acb58f9442035d28
Source dataset
uspto-grants-1988_01
Patent number
US04719049

Reaction notes

Loading…