3-Ethyl-6-(trifluoromethyl)-1-benzothiophene-2-carbaldehyde → Methyl 3-[4-[3-[3-ethyl-6-(trifluoromethyl)benzothiophen-2-yl]propenoyl]-2-methylphenyl]acrylate
Reaction equation
[CH2:1]([C:3]1[C:7]2[CH:8]=[CH:9][C:10]([C:12]([F:15])([F:14])[F:13])=[CH:11][C:6]=2[S:5][C:4]=1[CH:16]=O)[CH3:2].[C:18]([C:21]1[CH:26]=[CH:25][C:24]([CH:27]=[CH:28][C:29]([O:31][CH3:32])=[O:30])=[C:23]([CH3:33])[CH:22]=1)(=[O:20])[CH3:19]>>[CH2:1]([C:3]1[C:7]2[CH:8]=[CH:9][C:10]([C:12]([F:13])([F:14])[F:15])=[CH:11][C:6]=2[S:5][C:4]=1[CH:16]=[CH:19][C:18]([C:21]1[CH:26]=[CH:25][C:24]([CH:27]=[CH:28][C:29]([O:31][CH3:32])=[O:30])=[C:23]([CH3:33])[CH:22]=1)=[O:20])[CH3:2]Participants
3
Procedure
The titled compound was prepared from 3-ethyl-6-(trifluoromethyl)benzothiophen-2-carboxaldehyde [WO 2005077926] (185 mg, 0.716 mmol) and methyl 3-(4-acetyl-2-methylphenyl)acrylate (156 mg, 0.715 mmol) in a procedure similar to that of Example 7 (1) as a yellow crystal (186 mg, yield 57%).
Sources & evidence
- ORD record
- ord-f4cc689d69a04b5f87487c4dc353d742
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08648208B2
Reaction notes
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