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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 241366Generated: November 1, 2026

3-Ethyl-6-(trifluoromethyl)-1-benzothiophene-2-carbaldehyde → Methyl 3-[4-[3-[3-ethyl-6-(trifluoromethyl)benzothiophen-2-yl]propenoyl]-2-methylphenyl]acrylate

https://huagongshe.com/reaction/241366

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Ethyl-6-(trifluoromethyl)-1-benzothiophene-2-carbaldehydeHCID 58917920—
ReactantMethyl 3-(4-acetyl-2-methylphenyl)acrylateHCID 66883900—
ProductMethyl 3-[4-[3-[3-ethyl-6-(trifluoromethyl)benzothiophen-2-yl]propenoyl]-2-methylphenyl]acrylateHCID 66883381—

Reaction Steps

The titled compound was prepared from 3-ethyl-6-(trifluoromethyl)benzothiophen-2-carboxaldehyde [WO 2005077926] (185 mg, 0.716 mmol) and methyl 3-(4-acetyl-2-methylphenyl)acrylate (156 mg, 0.715 mmol) in a procedure similar to that of Example 7 (1) as a yellow crystal (186 mg, yield 57%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08648208B2
Source datasetuspto-grants-2014_02
ORD IDord-f4cc689d69a04b5f87487c4dc353d742
Source noteuspto-grants-2014_02