HCID 54487808, compound → HCID 54390892, compound

HRID 2413702Notes

Reaction equation

HRID 2413702 reaction equation
[CH3:1][N:2]1[C:5](=[O:6])[CH2:4][C@H:3]1[C:7]([O:9]CC1C=CC=CC=1)=[O:8].[H][H]>CO.[Pd]>[CH3:1][N:2]1[C:5](=[O:6])[CH2:4][C@H:3]1[C:7]([OH:9])=[O:8]

Participants

5

Reactant 2

HCID 54487808HCID 54487808, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54390892HCID 54390892, compoundYield 97.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In 10 ml of methanol was dissolved 450 mg of compound (11) and 45 mg of 10% Pd-C was added to the solution followed by catalytic hydrogenation at ambient temperature under an atmospheric pressure of hydrogen. The catalyst was filtered off and the solvent was removed by distillation under reduced pressure to obtain 258 mg of (S)-1-methyl-4-oxo-2-azetidinecarboxylic acid (12).

Workup

  1. additionwas added to the solution
  2. filtrationThe catalyst was filtered off
  3. customthe solvent was removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-d486b7cdbee54fd58211f266dc427ea4
Source dataset
uspto-grants-1988_01
Patent number
US04719207

Reaction notes

Loading…