HCID 54137886, compound → HCID 53923542, compound

HRID 2413705Notes

Reaction equation

HRID 2413705 reaction equation
[CH:1]([O:3][CH2:4][N:5]1[C:8](=[O:9])[CH2:7][C@H:6]1[C:10]([O:12]CC1C=CC=CC=1)=[O:11])=[O:2].[H][H]>CO.[Pd]>[CH:1]([O:3][CH2:4][N:5]1[C:8](=[O:9])[CH2:7][C@H:6]1[C:10]([OH:12])=[O:11])=[O:2]

Participants

5

Reactant 2

HCID 54137886HCID 54137886, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 53923542HCID 53923542, compoundYield 94.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In 20 ml of methanol was dissolved 1.05 g of compound (16) and 100 mg of 10% Pd-C was added to the solution followed by catalytic hydrogenation at ambient temperature under atmospheric pressure of hydrogen. The catalyst was filtered off and the solvent was removed by distillation under reduced pressure to obtain 650 mg of (S)-1-formyloxymethyl-4-oxo-2-azetidinecarboxylic acid (17).

Workup

  1. additionwas added to the solution
  2. filtrationThe catalyst was filtered off
  3. customthe solvent was removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-79ece012461e41c0967a66b9042578aa
Source dataset
uspto-grants-1988_01
Patent number
US04719207

Reaction notes

Loading…